Pentylenetetrazol: Failure to Improve Memory in Mice
نویسندگان
چکیده
منابع مشابه
Pentylenetetrazol: failure to improve memory in mice.
Pentylenetetrazol purportedly improves memory in mice. Irwin and Benuazizi (1) suggested that pretrial doses of pentylenetetrazol improve short-term retention, that posttrial doses improve longer-term retention, and that the doses that facilitate retention are much less than those that produce convulsions. We tried to confirm the salient parts of their findings. Our method was similar to theirs...
متن کاملIvabradine Reduces Seizures in Pentylenetetrazol- Kindled Mice
Methods: Forty Mice were randomly allocated into 4 equal groups; control, PTZ, diazepam (4mg/kg) and ivabradine (10 mg/kg) groups. Kindling model was produced by repeated i.p. administration of PTZ (40mg/kg), every other day for 9 days. Repeated PTZ treatment progressively increased the seizure score with the maximum score reached on day 9. Diazepam and ivabradine were administered intraperiton...
متن کاملMontelukast reduces seizures in pentylenetetrazol-kindled mice.
Cysteinyl leukotrienes (CysLTs) have been implicated in seizures and kindling; however, the effect of CysLT receptor antagonists on seizure frequency in kindled animals and changes in CysLT receptor expression after pentylenetetrazol (PTZ)-induced kindling have not been investigated. In this study, we evaluated whether the CysLT1 inverse agonist montelukast, and a classical anticonvulsant, phen...
متن کاملAnticonvulsant Effect of Guaifenesin against Pentylenetetrazol-Induced Seizure in Mice
Background: There have been some reports about the possible N-methyl-D-aspartate (NMDA) antagonist activity of Guaifenesin. As drugs with a similar structure to Guaifenesin (i.e. Felbamate) and those with NMDA antagonist activity have been clinically used as anticonvulsants, the aim of this study was to determine whether Guaifenesin has an anticonvulsant effect in an animal model of seizure. ...
متن کاملPentylenetetrazol and strychnine convulsions in brain weight selected mice
The seizure sensitivities to pentylenetetrazol (Ptz, 25-100 mg/kg) and strychnine (S, 2 mg/kg) were tested in two mice lines selected for large (LB) and small (SB) brain weight (brain weight difference being approximately 75 mg). The selection was based on a regression line connecting body and brain weight. SB mice were more sensitive to both drugs-their seizure latencies were shorter and letha...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 1967
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.157.3785.220